2011•PubMedRequires access

[Abnormal increase in CD8(low) T lymphocyte in patients with occupational chronic lead poisoning].

Wei Yu, Ying Luo, Jiayu Chen, Wei Wei Liu, Ling-zhen Chen, Jinmin Wu, Yu Zhan, Bo Li, Yangqiu Li

Abstract

OBJECTIVE: To analyze the changes in CD8(low) T lymphocyte subsets in patients with occupational chronic lead poisoning. METHODS: Flow cytometric analysis was used to count the numbers of CD8+ cells. 23 patients with occupational chronic lead poisoning and 20 controls were examined. RESULTS: Compared with control group (8.21% ± 3.02%), the CD8(low) T lymphocyte (12.98% ± 5.62%) were significantly increased in patients with occupational chronic lead poisoning. CONCLUSION: Although the ratio of CD+ T lymphocyte is normal, the CD8 level is significantly decreased. The increase of CD8(low) T lymphocyte may be an important phenomenon of immuno-injury induced by lead. CD8(low) T lymphocyte could be an new direction for research of lead immuno-toxicity.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Lead poisoning, CD8, Lymphocyte subsets, Lymphocyte, T lymphocyte, Immune system, Lead (geology), Medicine