1979•Thrombosis and HaemostasisRequires access

Tranexamic Acid and Gastric Fibrinolysis in the Rat

Björn Stenberg, Bo Risberg, Hans‐Inge Peterson

Abstract

An optimal inhibition of tissue fibrinolysis, studied by a histochemical fibrin slide technique in the rat stomach, was obtained by administration of tranexamic acid in a dose of 60 mg/100 g body weight. A significant fibrinolysis inhibition was found within 5 min, when tranexamic acid in this dose was given either intravenously or intragastrically. A prolonged duration of fibrinolysis inhibition was observed after intragastric administration. After 4 hr no inhibitory effect of tranexamic acid could be recorded, irrespective of the route of administration.

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Key concepts: Tranexamic acid, Fibrinolysis, Fibrin, Medicine, Stomach, Antifibrinolytic, Pharmacology, Anesthesia