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Recombinant immunotoxins: new therapeutic agents for cancer treatment.

Pastan Ih

Abstract

We have developed new agents for the treatment of cancer by genetically modifying Pseudomonas exotoxin. We have deleted the cell-binding region of Pseudomonas exotoxin and replaced it with various growth factors or the combining regions of antibodies in a single chain form. These new recombinant molecules are called recombinant toxins. Several different types of recombinant toxins have been produced. B3(Fv)-PE38KDEL is a recombinant toxin that kills many different adenocarcinomas and epidermoid carcinomas. The molecule is now undergoing preclinical development.

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Key concepts: Immunotoxin, Pseudomonas exotoxin, Recombinant DNA, Exotoxin, Toxin, Antibody, Cancer, Microbiology