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2003•Unpublished venueRequires access

MMP-2和MMP-9在乳腺癌中的表達及其意義

謝偉, 馮茂輝, 王維娜, 袁宏銀, 胡名柏, 程伏林, 龔玲玲

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Abstract

To study the expression of matrixmetalloproteinase (MMP)-2 and -9 and its significance in benign breast disease and breast carcinoma. Methods: Expression of MMP-2 and -9 was observed by SP immunohistochemical technique in 12 benign breast diseases and 32 breast carcinomas. Results: Expression of MMP-2 and -9 in breast cancer was much higher than that in benign breast disease (P＜0.01). Compared with breast carcinomas without positive metastasis, expression of MMP-2 and -9 was upregulated in those with lymphnode metastasis (P＜0.05). Conclusion: MMP-2 and -9 may play an important role in the invasion and metastasis of breast cancer.

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What this paper is about

To study the expression of matrixmetalloproteinase (MMP)-2 and -9 and its significance in benign breast disease and breast carcinoma. Methods: Expression of MMP-2 and -9 was observed by SP immunohistochemical technique in 12 benign breast diseases and 32 breast carcinomas. Results: Expression of MMP-2 and -9 in breast cancer was much higher than that in benign breast disease (P＜0.01). Compared with breast carcinomas without positive metastasis, expression of MMP-2 and -9 was upregulated in those with lymphnode metastasis (P＜0.05). Conclusion: MMP-2 and -9 may play an important role in the invasion and metastasis of breast cancer.

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Available abstract

To study the expression of matrixmetalloproteinase (MMP)-2 and -9 and its significance in benign breast disease and breast carcinoma. Methods: Expression of MMP-2 and -9 was observed by SP immunohistochemical technique in 12 benign breast diseases and 32 breast carcinomas. Results: Expression of MMP-2 and -9 in breast cancer was much higher than that in benign breast disease (P＜0.01). Compared with breast carcinomas without positive metastasis, expression of MMP-2 and -9 was upregulated in those with lymphnode metastasis (P＜0.05). Conclusion: MMP-2 and -9 may play an important role in the invasion and metastasis of breast cancer.

Key concepts: Breast cancer, Breast carcinoma, Metastasis, Medicine, Matrix metalloproteinase, Immunohistochemistry, Oncology, Pathology

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