2004•PubMedRequires access

[The antitumor activities of the extracts from Stellera chamaejasmel L. in vitro by means of systematic solvent extraction].

Bin Wang, Rui Wang, Zhengping Jia, Junjie Fan, Jun Ma, Ruxue Zhang

Abstract

OBJECTIVE: To screen the antitumor extract from Stellera chamaejasmel L.. METHODS: The means of systematic solvent extraction was used to separate the 95% ethanol extract. The antitumor activities of the different extracts in vitro were analyzed with MTT assay. RESULTS: The petroleum ether extract and the chloroform extract strongly inhibited cell proliferation of human cancer cell lines such as leukemia HL-60, stomach cancer SGC-7901 and hepatocarcinoma BEL-7402, and showed significant dose-dependent response while the n-butanol extract and the methanol extract exhibited low antitumor activities in vitro. The petroleum ether extract was most active. CONCLUSION: The petroleum ether extract is the principal antitumor extract from Stellera chamaejasmel L..

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Key concepts: Petroleum ether, Chloroform, In vitro, Chemistry, Butanol, Ethanol, Extraction (chemistry), Ether