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Fluoxetine and the bleeding time.

John Eric Humphries, M S Wheby, Scott R. VandenBerg

Abstract

Fluoxetine (Prozac) is a nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitor commonly prescribed for the treatment of depression. Fluoxetine also blocks 5-hydroxytryptamine reuptake in platelets and could potentially lead to clinically significant platelet dysfunction. We describe a patient who developed petechiae and prolongation of the bleeding time while receiving fluoxetine therapy.

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Key concepts: Fluoxetine, Serotonin reuptake inhibitor, Reuptake inhibitor, Platelet, Serotonin, Medicine, Serotonin Uptake Inhibitors, Depression (economics)