2001•Nihon Naika Gakkai ZasshiOpen access

Chronic obstructive pulmonary disease (COPD). Advances in diagnosis and treatment. I. Diagnosis and pathological state. 6 Air duct inflammation.

T Orui, 山谷睦雄, Misa Yanai, H. Sasaki

Abstract

慢性閉塞性肺疾患(chronic obstructive pulmonary disease: COPD)の発症には,喫煙や大気汚染に伴い生じる気道から肺胞領域にわたる広汎な炎症が重要である. COPDの炎症に関与する細胞として,マクロファージ,好中球が重要視されてきたが,近年CD8+Tリンパ球,好酸球の他に気道上皮細胞の役割が明らかにされてきた.喫煙などにより,肺内に集積した炎症細胞がプロテアーゼや活性酸素を放出し,防御機構を凌駕し気道および肺胞系の破壊が生じる.

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Key concepts: Medicine, Pathological, COPD, Pulmonary disease, Inflammation, Disease, Duct (anatomy), Intensive care medicine