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Laser Light Induced Modification of the Mice Peripheral Blood Parameters and the Number of Bone Marrow Karyocytes after the Action of Ionizing Radiation

Karine Voskanyan, Vorozhtsova Sv, Alla Abrosimova, G. V. Mitsyn, V. N. Gaevsky

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Abstract

This study assessed the effect of exposure to various doses of 650 nm laser radiation, as well as of the combined irradiation to laser radiation and γ-rays^60Со (3 Gy) on the level of hemoglobin and leukocytes in peripheral blood and bone marrow karyocytes of C57BL/6 mice. The mice were irradiated with ionizing and laser radiation, separately one by one in a special frame device. Laser radiation in the dose 1 mJ/cm^2 irradiated only the back of a mouse, or both the back and the abdomen of mice. In case of combined irradiation of mice, the time interval between two types of irradiation did not exceed 30 min. First the mice were exposed to γ-radiation, then to laser radiation. The obtained results show that laser radiation stimulates blood cell formation not only in the case of irradiation with laser, but also after action of ionizing radiation. Therefore, the red spectral range laser radiation can be applied to improve the recovery of hematogenesis after the action of ionizing radiation on biological objects.

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What this paper is about

This study assessed the effect of exposure to various doses of 650 nm laser radiation, as well as of the combined irradiation to laser radiation and γ-rays^60Со (3 Gy) on the level of hemoglobin and leukocytes in peripheral blood and bone marrow karyocytes of C57BL/6 mice. The mice were irradiated with ionizing and laser radiation, separately one by one in a special frame device. Laser radiation in the dose 1 mJ/cm^2 irradiated only the back of a mouse, or both the back and the abdomen of mice. In case of combined irradiation of mice, the time interval between two types of irradiation did not exceed 30 min. First the mice were exposed to γ-radiation, then to laser radiation. The obtained results show that laser radiation stimulates blood cell formation not only in the case of irradiation with laser, but also after action of ionizing radiation. Therefore, the red spectral range laser radiation can be applied to improve the recovery of hematogenesis after the action of ionizing radiation on biological objects.

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Available abstract

This study assessed the effect of exposure to various doses of 650 nm laser radiation, as well as of the combined irradiation to laser radiation and γ-rays^60Со (3 Gy) on the level of hemoglobin and leukocytes in peripheral blood and bone marrow karyocytes of C57BL/6 mice. The mice were irradiated with ionizing and laser radiation, separately one by one in a special frame device. Laser radiation in the dose 1 mJ/cm^2 irradiated only the back of a mouse, or both the back and the abdomen of mice. In case of combined irradiation of mice, the time interval between two types of irradiation did not exceed 30 min. First the mice were exposed to γ-radiation, then to laser radiation. The obtained results show that laser radiation stimulates blood cell formation not only in the case of irradiation with laser, but also after action of ionizing radiation. Therefore, the red spectral range laser radiation can be applied to improve the recovery of hematogenesis after the action of ionizing radiation on biological objects.

Key concepts: Ionizing radiation, Irradiation, Laser, Radiation, Bone marrow, Nuclear medicine, Chemistry, Materials science

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Laser Light Induced Modification of the Mice Peripheral Blood Parameters and the Number of Bone Marrow Karyocytes after the Action of Ionizing Radiation — Research Paper | ScholarLens