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[Medical treatment of Cushing syndrome].

Franco Mantero, Nicoletta Sonino

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Abstract

Cushing's syndrome is a serious endocrine condition for which no treatment has been proven fully satisfactory at least for its pituitary dependent form (Cushing's disease). Indeed, despite some advances in pharmacology (cyproheptadine, bromocriptine, lisuride) and in surgical and radiation procedures at pituitary level, a definitive cure is often delayed. The inhibitors of steroids synthesis (ketoconazole, aminoglutethimide, metyrapone, mitotane) are still very valuable tools in its management as a palliative treatment.

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What this paper is about

Cushing's syndrome is a serious endocrine condition for which no treatment has been proven fully satisfactory at least for its pituitary dependent form (Cushing's disease). Indeed, despite some advances in pharmacology (cyproheptadine, bromocriptine, lisuride) and in surgical and radiation procedures at pituitary level, a definitive cure is often delayed. The inhibitors of steroids synthesis (ketoconazole, aminoglutethimide, metyrapone, mitotane) are still very valuable tools in its management as a palliative treatment.

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Available abstract

Cushing's syndrome is a serious endocrine condition for which no treatment has been proven fully satisfactory at least for its pituitary dependent form (Cushing's disease). Indeed, despite some advances in pharmacology (cyproheptadine, bromocriptine, lisuride) and in surgical and radiation procedures at pituitary level, a definitive cure is often delayed. The inhibitors of steroids synthesis (ketoconazole, aminoglutethimide, metyrapone, mitotane) are still very valuable tools in its management as a palliative treatment.

Key concepts: Medicine, Mitotane, Aminoglutethimide, Bromocriptine, Metyrapone, Ketoconazole, Pituitary tumors, Cushing syndrome

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