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[Model of the packing of DNA and histone octamer in the structure of the nucleosome].

Sergei N. Khrapunov, Andrei Sivolob, Berdyshev Gd

Abstract

A model is proposed which describes the packing of polypeptide chains of histone molecules in the octamer (H3--H4--H2A--H2B)2, and interlocation of DNA and octamer in the nucleosome. DNA packing in the nucleosome is provided for by electrostatic interactions between DNA phosphates and cationic groups located on the globular part surface of histones octamer. The cationic groups of N- and C-end regions of the histone molecules (histones H3 and H4 in particular) additionally stabilize the nucleosome structure.

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Key concepts: Histone octamer, Nucleosome, Histone, Chromatosome, DNA, Biophysics, Linker DNA, Chemistry