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[Prevention of post-ovariectomy osteoporosis in the rat. Comparative study of synthetic salmon calcitonin and eel calcitonin aminosuberic analogue].

S Gnudi, A. Zati, Roberto Giardino, Milena Fini, Loredana Pratelli, Lorenza Maria Landi, Elisabetta Figus

Abstract

The authors evaluate the efficacy of salmon calcitonin and aminosuberic analogue of eel calcitonin in the prevention of post-oophorectomy osteoporosis in rats. Both drugs, administered at the same dosage, are equally effective in preventing oophorectomy bone loss in rats. Besides, plasma biochemical evaluations demonstrate that calcitonins reduce bone turnover in treated rats, compared with control oophorectomized ones.

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Key concepts: Salmon calcitonin, Medicine, Calcitonin, Osteoporosis, Oophorectomy, Endocrinology, Internal medicine, Bone remodeling