[The primary structure of the hemagglutinin gene of strain A/Riga/9977/86--a drift variant of influenza virus A(H3N2)].
Petrov Na, Vasilenko Sk, Iu A Gorbunov, Vtorushina Ia, Grinbaum Eb, Litvinova Om, T Ia Luzianina, Golubev Db
Abstract
Petrov Na, Vasilenko Sk, Iu A Gorbunov, Vtorushina Ia, Grinbaum Eb, Litvinova Om, T Ia Luzianina, Golubev Db
Abstract
The hemagglutinin gene primary structure of influenza virus A/Riga/9977/86 (H3N2) belonging to the "Coen/84" antigenic subgroup was determined by primer sequencing. A comparative analysis confirmed that the reversions of amino acids in the late stages of the H3 influenza virus subtype antigenic drift became more frequent and the antigenic variants remained in epidemic circulation longer. The possible role of some mutations is discussed.
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The hemagglutinin gene primary structure of influenza virus A/Riga/9977/86 (H3N2) belonging to the "Coen/84" antigenic subgroup was determined by primer sequencing. A comparative analysis confirmed that the reversions of amino acids in the late stages of the H3 influenza virus subtype antigenic drift became more frequent and the antigenic variants remained in epidemic circulation longer. The possible role of some mutations is discussed.
Key concepts: Hemagglutinin (influenza), Antigenic drift, Virology, Virus, Gene, Antigenic shift, Biology, Influenza A virus