2000•PubMedRequires access

[The influence of calcium channel blockers on the effects of anxiogenic preparations].

Kozlovskiĭ Vl

Abstract

The effect of anxiogenic drugs (caffeine, pentilentetrazole, phenilethylamine, strophantine, BAY K 8644) on SHR mice' behavior was studied in the dark-light chamber test. All these drugs have diminished the number of transitions between the chambers. Pretreatment with verapamil, nifedipine, cinnarizine and fendilin have not altered the effect of relevant anxiogenic drugs. Diltiazem prevented the effect of stophantine. It is suggested that the lack of the effect of calcium channel blockers on the action of anxiogens is related to peculiarities of formation of anxiety in this test.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Diltiazem, Anxiogenic, Verapamil, Cinnarizine, Nifedipine, Calcium channel, Pharmacology, Caffeine