[Effect of adrenergic beta-receptor blockers on the oxygen consumption or narcotized rats and the calorigenic action of adrenaline].

The adrenergic beta-receptor blockers: Propranolol, Alprenolol, Oxprenolol, Pindolol, Practolol, and Talinolol, inhibit the calorigenic action of adrenaline in experiments on rats. These findings doe not permit any quantitative comparison, because the beta blockers show considerable differences in their inherent action on the basic metabolism. THe cardioselective beta-blockers, Practolol and Talinolol, are without effect, while Propanolol increases, and Alprenolol, Oxprenolol and Pindolol lower the basic metabolism. The intrinsic activity of these compounds increases with the decrease of their hydrophobicity.