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Determination of salicilic acid in saliva by high-performance liquid chromatography.

Vanni Cavrini, Rita Gatti, Anna Maria Di Pietra

Abstract

A sensitive reversed-phase HPLC method with fluorimetric detection was developed for the determination of salicilic acid in saliva samples. The method, involving a preliminary solid-phase extraction procedure, was found to be suitable for the determination of salivary salicilic acid concentrations following the administration of a single oral dose of some commercial acetylsalicilic acid formulations.

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Available abstract

Key concepts: Chromatography, Saliva, Chemistry, High-performance liquid chromatography, Reversed-phase chromatography, Extraction (chemistry), Solid phase extraction, Biochemistry