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Monoamine metabolites in human cerebrospinal fluid: indicators of neuronal activity?

Mika Scheinin

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Abstract

Concentrations of monoamine metabolites in human cerebrospinal fluid (CSF) have been widely used as indicators of the level of functional activity in the central monoaminergic neuronal pathways. This article reviews the relationship between the turnover of the neurotransmitter monoamines noradrenaline, serotonin, and dopamine, and the concentrations in CSF of their principal metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA). It attempts to summarise what is known of the effects of various illnesses and drug treatments on the concentrations of these metabolites.

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What this paper is about

Concentrations of monoamine metabolites in human cerebrospinal fluid (CSF) have been widely used as indicators of the level of functional activity in the central monoaminergic neuronal pathways. This article reviews the relationship between the turnover of the neurotransmitter monoamines noradrenaline, serotonin, and dopamine, and the concentrations in CSF of their principal metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA). It attempts to summarise what is known of the effects of various illnesses and drug treatments on the concentrations of these metabolites.

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OpenAlex reports 48 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Concentrations of monoamine metabolites in human cerebrospinal fluid (CSF) have been widely used as indicators of the level of functional activity in the central monoaminergic neuronal pathways. This article reviews the relationship between the turnover of the neurotransmitter monoamines noradrenaline, serotonin, and dopamine, and the concentrations in CSF of their principal metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA). It attempts to summarise what is known of the effects of various illnesses and drug treatments on the concentrations of these metabolites.

Key concepts: Homovanillic acid, Monoaminergic, Monoamine neurotransmitter, Cerebrospinal fluid, Dopamine, Serotonin, Neurotransmitter, Chemistry

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