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[Plasma hormone levels in rats with DMBA-induced mammary tumors].

Burenin Is, Piskareva Nk

Abstract

Development of the DMBA-induced breast cancer in rats resulted in an increase of the thyrotropin, somatotropin and prolactin concentrations in blood plasma. Thyroliberin (TRH) stimulation of the thyrotropin secretion was decreased. Basal levels of the corticotropin (ACTH) and lutropin (LH) as well as of the luliberin (LRH) stimulation of the LH secretion were not changed. Concentrations of estradiol, corticosterone and insulin enhanced, those of testosterone, progesterone and thyroxine lowered. Out of two calcitropic hormones, RTH and CT, the secretion of the latter increased.

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Key concepts: Internal medicine, Endocrinology, Prolactin, DMBA, Stimulation, Testosterone (patch), Hormone, Secretion