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Clinical utility of ketoconazole in cases of adrenocortical carcinoma.

Chittari Venkata Harinarayan, Shweta Gupta, A.C. Ammini, Madhu Ganesh Karmarkar, Rajiv Mohan Gupta, L. K. Sharma, M. M. S. Ahuja

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Abstract

Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size, one patient developed liver dysfunction which reverted back to normal on discontinuing the drug.

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What this paper is about

Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size, one patient developed liver dysfunction which reverted back to normal on discontinuing the drug.

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OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size, one patient developed liver dysfunction which reverted back to normal on discontinuing the drug.

Key concepts: Ketoconazole, Adrenocortical carcinoma, Medicine, Carcinoma, Steroid biosynthesis, Steroid, Urinary system, Cytochrome P450

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Clinical utility of ketoconazole in cases of adrenocortical carcinoma. — Research Paper | ScholarLens