[A change in the permeability of eye microvasculature during damage to the hypothalamic nuclei in intact and rats and rats pretreated with capsaicin].

The destruction of rat hypothalamic mamillary nuclei causes impaired permeability of eye microvessels receiving afferent innervation from the trigeminal ganglion. This effect was eliminated by pre-treatment of the animals with capsaicin (200 mg/kg), which exhausted the content of substance P and calcitonin-gene-specific peptide, from the primary capsaicin-sensitive neurons of trigeminal and spinal ganglia. The findings show that the peripheral effect caused by the destruction of mamillary nuclei is mediated through capsaicin-sensitive neurons of the trigeminal ganglion.