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[The in-vitro action of chloroquine on the infectivity of gametocytes of Plasmodium berghei Anka].

A Said, M Wéry

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Abstract

The influence of chloroquine on the infectivity of gametocytes of P. berghei Anka chloroquino-sensitive was assessed in vitro. It was found that chloroquine could not affect the exflagellation of microgametocytes but prevented the formation of ookinetes at the concentration of 10 micrograms/ml. This activity seemed to be stage and dose dependent.

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The influence of chloroquine on the infectivity of gametocytes of P. berghei Anka chloroquino-sensitive was assessed in vitro. It was found that chloroquine could not affect the exflagellation of microgametocytes but prevented the formation of ookinetes at the concentration of 10 micrograms/ml. This activity seemed to be stage and dose dependent.

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Available abstract

The influence of chloroquine on the infectivity of gametocytes of P. berghei Anka chloroquino-sensitive was assessed in vitro. It was found that chloroquine could not affect the exflagellation of microgametocytes but prevented the formation of ookinetes at the concentration of 10 micrograms/ml. This activity seemed to be stage and dose dependent.

Key concepts: Gametocyte, Plasmodium berghei, Infectivity, Chloroquine, In vitro, Biology, Mepacrine, Virology

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[The in-vitro action of chloroquine on the infectivity of gametocytes of Plasmodium berghei Anka]. — Research Paper | ScholarLens