[The diuretic activity of bumetanide in a controlled comparison with furosemide in patients with various degrees of impaired renal function (author's transl)].

The effect of bumetanide (6 and 12 mg) was compared with that of furosemide (250 and 500 mg) in 13 patients with chronic renal insufficiency in a double-blind study using each patient as his own control. In the dose ratio of 1:40 previously obtained in normal subjects furosemide showed a significantly higher diuretic response than bumetanide. Comparing the relative natriuretic effects in chronic renal insufficiency a ratio of 1:10 to 1:12 (B:F) seemed to be adequate. More than 12 mg bumetanide cannot be recommended because of the severe muscle pains which occurred in all patients with that dosage.