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1979•Southern Medical JournalRequires access

Treatment of Pneumocystis carinii Pneumonia With Trimethoprim-Sulfamethoxazole and Pentamidine

James E. Milder, Peter D. Walzer, Ralph D. Powell

Open publisher page 7 citations

Abstract

A 39-year-old man with Pneumocystis carinii pneumonia responded poorly to oral trimethoprim-sulfamethoxazole (TMP-SMX) therapy, despite excellent serum concentrations of the drug. He developed severe thrombocytopenia when pentamidine was added to the regimen. This case illustrates problems of drug efficacy and toxicity in the treatment of P carinii pneumonia and suggests caution in the use of TMP-SMX and pentamidine in combination.

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What this paper is about

A 39-year-old man with Pneumocystis carinii pneumonia responded poorly to oral trimethoprim-sulfamethoxazole (TMP-SMX) therapy, despite excellent serum concentrations of the drug. He developed severe thrombocytopenia when pentamidine was added to the regimen. This case illustrates problems of drug efficacy and toxicity in the treatment of P carinii pneumonia and suggests caution in the use of TMP-SMX and pentamidine in combination.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A 39-year-old man with Pneumocystis carinii pneumonia responded poorly to oral trimethoprim-sulfamethoxazole (TMP-SMX) therapy, despite excellent serum concentrations of the drug. He developed severe thrombocytopenia when pentamidine was added to the regimen. This case illustrates problems of drug efficacy and toxicity in the treatment of P carinii pneumonia and suggests caution in the use of TMP-SMX and pentamidine in combination.

Key concepts: Pneumocystis carinii, Pentamidine, Trimethoprim, Medicine, Sulfamethoxazole, Pneumonia, Regimen, Drug

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Treatment of Pneumocystis carinii Pneumonia With Trimethoprim-Sulfamethoxazole and Pentamidine — Research Paper | ScholarLens