2004•PubMedRequires access

Effects of tail suspension on electrophysiological characteristics of muscle spindles in isolated rat soleus muscle.

Bin Tang, Xiaoli Fan, Su-di Wu

Abstract

OBJECTIVE: To study changes in electrophysiological characteristics of muscle spindles induced by simulated weightlessness in isolated rats soleus. METHOD: Weightlessness was simulated by tail-suspension in female rats. Using electro-physiological technique, the spontaneous discharge of muscle spindle and its response to ramp-and-hold stretch were observed in isolated soleus of 7 d, 14 d tail-suspended and control rats. RESULT: Soleus muscle spindles of rat manifest a sharp decrease in spontaneous discharge frequency and the response to ramp-and-hold stretch after 7 d tail-suspension. More significant changes were observed in rats after 14 d tail-suspension. CONCLUSION: Simulated weightlessness could induce time-related changes in electrophysiological characteristics of soleus muscle spindles in rat.

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Key concepts: Weightlessness, Soleus muscle, Electrophysiology, Muscle spindle, Suspension (topology), Anatomy, Chemistry, Biophysics