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[Investigational treatment of cancer using electrochemotherapy, electrochemoimmunotherapy and electro-gene transfer].

Julie Gehl

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Abstract

Electroporation is the use of short, high-voltage pulses to transiently permeabilize the cell membrane. This technique can be used to increase the cellular uptake of otherwise non-permeating molecules, e.g., cytotoxic agents (electrochemotherapy). The electrochemotherapy area can also be used as a tumorlysis product in connection with immunotherapy. New avenues are opening for the clinical use of electroporation in non-viral gene delivery.

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What this paper is about

Electroporation is the use of short, high-voltage pulses to transiently permeabilize the cell membrane. This technique can be used to increase the cellular uptake of otherwise non-permeating molecules, e.g., cytotoxic agents (electrochemotherapy). The electrochemotherapy area can also be used as a tumorlysis product in connection with immunotherapy. New avenues are opening for the clinical use of electroporation in non-viral gene delivery.

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OpenAlex reports 14 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Electroporation is the use of short, high-voltage pulses to transiently permeabilize the cell membrane. This technique can be used to increase the cellular uptake of otherwise non-permeating molecules, e.g., cytotoxic agents (electrochemotherapy). The electrochemotherapy area can also be used as a tumorlysis product in connection with immunotherapy. New avenues are opening for the clinical use of electroporation in non-viral gene delivery.

Key concepts: Electrochemotherapy, Electroporation, Gene transfer, Cytotoxic T cell, Cancer research, Bleomycin, Genetic enhancement, Gene delivery

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[Investigational treatment of cancer using electrochemotherapy, electrochemoimmunotherapy and electro-gene transfer]. — Research Paper | ScholarLens