[Investigational treatment of cancer using electrochemotherapy, electrochemoimmunotherapy and electro-gene transfer].
Julie Gehl
Abstract
Julie Gehl
Abstract
Electroporation is the use of short, high-voltage pulses to transiently permeabilize the cell membrane. This technique can be used to increase the cellular uptake of otherwise non-permeating molecules, e.g., cytotoxic agents (electrochemotherapy). The electrochemotherapy area can also be used as a tumorlysis product in connection with immunotherapy. New avenues are opening for the clinical use of electroporation in non-viral gene delivery.
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Electroporation is the use of short, high-voltage pulses to transiently permeabilize the cell membrane. This technique can be used to increase the cellular uptake of otherwise non-permeating molecules, e.g., cytotoxic agents (electrochemotherapy). The electrochemotherapy area can also be used as a tumorlysis product in connection with immunotherapy. New avenues are opening for the clinical use of electroporation in non-viral gene delivery.
Key concepts: Electrochemotherapy, Electroporation, Gene transfer, Cytotoxic T cell, Cancer research, Bleomycin, Genetic enhancement, Gene delivery