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[Monotherapy with clobazam in epilepsies in children].

Olivier Dulac, David J. Figueroa, Enrique Rey, M Arthuis

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Abstract

Twenty-five epileptic children were treated with clobazam alone for periods of 10 days to 36 months (mean = 9 months and 16 months for children who responded well). Satisfactory results were obtained in 11 patients and marked improvement with a 75% decrease in the initial frequency of seizures in 6 patients. The seizures recurred after a few weeks in 3 other patients. This preliminary study shows that clobazam is well tolerated and remarkably effective, especially in benign partial epilepsy, even in carbamazepine-resistant cases.

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What this paper is about

Twenty-five epileptic children were treated with clobazam alone for periods of 10 days to 36 months (mean = 9 months and 16 months for children who responded well). Satisfactory results were obtained in 11 patients and marked improvement with a 75% decrease in the initial frequency of seizures in 6 patients. The seizures recurred after a few weeks in 3 other patients. This preliminary study shows that clobazam is well tolerated and remarkably effective, especially in benign partial epilepsy, even in carbamazepine-resistant cases.

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OpenAlex reports 30 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Twenty-five epileptic children were treated with clobazam alone for periods of 10 days to 36 months (mean = 9 months and 16 months for children who responded well). Satisfactory results were obtained in 11 patients and marked improvement with a 75% decrease in the initial frequency of seizures in 6 patients. The seizures recurred after a few weeks in 3 other patients. This preliminary study shows that clobazam is well tolerated and remarkably effective, especially in benign partial epilepsy, even in carbamazepine-resistant cases.

Key concepts: Clobazam, Medicine, Carbamazepine, Partial epilepsy, Epilepsy, Anesthesia, Anticonvulsant, Pediatrics

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