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Hypotensive effects of eicosapentaenoic acid (EPA) and its influence on eicosanoid metabolism in spontaneously hypertensive rats.

Lam Bk, E Marcinkiewicz, John Quilley, A Hirai, Sayaka Yoshida, Yasushi Tamura, Wong Py

Abstract

Oral administration of pure eicosapentaenoic acid (EPA) ethyl ester caused a reversible hypotensive effect in spontaneously hypertensive rats. Treatment with EPA also lowered the platelet response to ADP and inhibited the conversion of leucotrienes (LTs) A4 and LTB4 and other sulphidopeptide leucotrienes. Therefore, diet supplemented with EPA may lower blood pressure in hypertensive rats and affect cardiovascular functions which may be mediated through eicosanoid metabolism.

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Key concepts: Eicosapentaenoic acid, Eicosanoid metabolism, Medicine, Eicosanoid, Metabolism, Blood pressure, Endocrinology, Internal medicine