Michael A. Mohutsky, Stephen David Hall
Abstract
This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions.
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This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions.
Key concepts: Drug, Enzyme inhibition, Pharmacology, Enzyme, Chemistry, Kinetics, Enzyme kinetics, Medicine