1995•PubMedRequires access

Localization of type-1 porin channel (VDAC) in the sarcoplasmatic reticulum.

Ludger Jürgens, Jochen W. Kleineke, Dieter G. Brdiczka, Friedrich Peter THINNES, NORBERT HILSCHMANN

Abstract

Eucaryotic porin channels or voltage-dependent anion channels (VDACs) are expressed in the outer mitochondrial membranes and in the plasmalemma of mammalian cells. Subfractions of sarcoplasmatic reticulum (SR) obtained from rabbit skeletal muscle display type-1 porin channels in transverse tubuli (TT) when analysed by immunoblot analysis with type-1 porin specific monoclonal antibodies. These data are in agreement with our recent proposal suggesting the presence of porin channels in non-mitochondrial eucaryotic membranes.

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Key concepts: Voltage-dependent anion channel, Porin, Endoplasmic reticulum, Membrane, Ion channel, Monoclonal antibody, Chemistry, Biophysics