Effect of collagen on thrombin inactivation by antithrombin-III and heparin.
G Blaskó, John F. Bedi, Raymund Machovich, Pálos La
Abstract
G Blaskó, John F. Bedi, Raymund Machovich, Pálos La
Abstract
Thrombin inactivation by antithrombin-III and heparin has been found to decrease in the presence of collagen, whereas thrombin activity and the rate of thrombin inactivation by antithrombin-III alone are not affected. Albumin, at the same concentration as collagen, does not influence either thrombin activity or thrombin inactivation by antithrombin-III or by antithrombin-III plus heparin.
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Thrombin inactivation by antithrombin-III and heparin has been found to decrease in the presence of collagen, whereas thrombin activity and the rate of thrombin inactivation by antithrombin-III alone are not affected. Albumin, at the same concentration as collagen, does not influence either thrombin activity or thrombin inactivation by antithrombin-III or by antithrombin-III plus heparin.
Key concepts: Thrombin, Antithrombin, Heparin, Chemistry, Biochemistry, Albumin, Pharmacology, Internal medicine