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[Cerebrospinal fluid parameters in Guillain-Barré polyradiculitis. Importance of barrier disorder and intrathecal immunoglobulin synthesis].

R Papen, Krystyna Warecka

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Abstract

With routine CSF determination of 21 patients with GBS the BBB and the intrathecal IgG synthesis was investigated when calculated CSF/serum albumin ratio and CSF IgG-index respectively. Only in 2 of 21 patients (9.5%) an intrathecal IgG synthesis and in 14 of 21 patients (67%) a BBB damage was found. The BBB was considered as an important pathogenetic factor in GBS. A hypothesis for the development of the albumino-cytological dissociation is presented.

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What this paper is about

With routine CSF determination of 21 patients with GBS the BBB and the intrathecal IgG synthesis was investigated when calculated CSF/serum albumin ratio and CSF IgG-index respectively. Only in 2 of 21 patients (9.5%) an intrathecal IgG synthesis and in 14 of 21 patients (67%) a BBB damage was found. The BBB was considered as an important pathogenetic factor in GBS. A hypothesis for the development of the albumino-cytological dissociation is presented.

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Available abstract

With routine CSF determination of 21 patients with GBS the BBB and the intrathecal IgG synthesis was investigated when calculated CSF/serum albumin ratio and CSF IgG-index respectively. Only in 2 of 21 patients (9.5%) an intrathecal IgG synthesis and in 14 of 21 patients (67%) a BBB damage was found. The BBB was considered as an important pathogenetic factor in GBS. A hypothesis for the development of the albumino-cytological dissociation is presented.

Key concepts: Intrathecal, Cerebrospinal fluid, Guillain-Barre syndrome, Antibody, CSF albumin, Medicine, Albumin, Immunoglobulin G

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[Cerebrospinal fluid parameters in Guillain-Barré polyradiculitis. Importance of barrier disorder and intrathecal immunoglobulin synthesis]. — Research Paper | ScholarLens