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Analgesic and side effects of pentazocine and morphine in a large population of postoperative patients

Richard Paddock, E. George Beer, J. Weldon Bellville, Benjamin J. Ciliberti, William H. Forrest, Elliott V. Miller

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Abstract

The analgesic and side effects of pentazocine were compared with those of morphine in 1,074 surgical patients. Three separate three‐point assays were conducted. Standard doses used were 5 mg. and 10 mg. of morphine and 10 mg., 20 mg., and 40 mg. of pentazocine. The relative analgesic potency, based on a 225 minute time period for analgesic effect, was 0.28 (36 mg. of pentazocine ≃ 10 mg. of morphine). For peak pain intensity difference, the relative potency was found to be 0.38 (27 mg. of pentazocine ≃ 10 mg. of morphine).

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What this paper is about

The analgesic and side effects of pentazocine were compared with those of morphine in 1,074 surgical patients. Three separate three‐point assays were conducted. Standard doses used were 5 mg. and 10 mg. of morphine and 10 mg., 20 mg., and 40 mg. of pentazocine. The relative analgesic potency, based on a 225 minute time period for analgesic effect, was 0.28 (36 mg. of pentazocine ≃ 10 mg. of morphine). For peak pain intensity difference, the relative potency was found to be 0.38 (27 mg. of pentazocine ≃ 10 mg. of morphine).

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OpenAlex reports 46 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The analgesic and side effects of pentazocine were compared with those of morphine in 1,074 surgical patients. Three separate three‐point assays were conducted. Standard doses used were 5 mg. and 10 mg. of morphine and 10 mg., 20 mg., and 40 mg. of pentazocine. The relative analgesic potency, based on a 225 minute time period for analgesic effect, was 0.28 (36 mg. of pentazocine ≃ 10 mg. of morphine). For peak pain intensity difference, the relative potency was found to be 0.38 (27 mg. of pentazocine ≃ 10 mg. of morphine).

Key concepts: Pentazocine, Morphine, Analgesic, Potency, Medicine, Anesthesia, Chemistry, Biochemistry

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