2005•PubMedRequires access

[Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia].

Pan Hong-ping, Xiang-lan Mo, Yang Jia-zhen, Lu-li Li, Zhaohan Huang, Ye Jin, Jin Huang

Abstract

OBJECTIVE: To study the effect of puerarin on the expression of Hsp (heat shock protein) 70 in the rats with cerebral injury induced by acute local ischemia. METHOD: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The Hsp70 expression in brain tissue was detected by SP method of immunohistochemistry. RESULT: The expression of Hsp70 was significantly higher in puerarintreated rats than those in the rats with cerebral ischemia. CONCLUSION: Puerarin can enhance the level of Hsp70 expression in the rats with cerebral injury induced by acute local ischemia.

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Key concepts: Puerarin, Hsp70, Ischemia, Middle cerebral artery, Immunohistochemistry, Medicine, Heat shock protein, Anesthesia