[Chronotherapeutic evaluation of the antihypertensive treatment].

Blood pressure, as well as other biological parameters, shows a circadian rhythm with a morning increase following the nocturnal blood pressure fall. In a parallel way, and probably related, there is a characteristic morning concentration of cardiovascular events. The antihypertensive treatment should pursue normotension during the 24 hours of the day, by restrictive the morning blood pressure increase. Drug efficacy can be improved depending on the time of the day of drug dose. Chronotherapeutical effects of different drugs in blood pressure are discussed.