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In vitro activities of seven quinolone derivatives against Neisseria gonorrhoeae.

A. H. van der Willigen, J. E. Degener, Miriam Vogel, Ernst Stolz, J.H.T. Wagenvoort

Abstract

The in vitro activities of ciprofloxacin, enoxacin, fleroxacin, lomefloxacin, norfloxacin, ofloxacin, and pefloxacin against 10 penicillinase-producing N. gonorrhoeae strains (PPNG's), 10 non-PPNG's, 10 non-penicillinase-producing penicillin-resistant chromosomally mediated N. gonorrhoeae strains (CMRNG's) 3 N. gonorrhoeae strains with a decreased sensitivity against quinolones compounds and one tetracycline-resistant penicillinase-producing N. gonorrhoeae (TRNG/PPNG), strain were evaluated in this study. The non PPNG, PPNG, CMRNG and TRNG/PPNG strains showed good to excellent sensitivity to the quinolones tested. The N. gonorrhoeae strains with a decreased sensitivity against quinolones showed higher MIC (minimum inhibitory concentration) values.

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Key concepts: Neisseria gonorrhoeae, Pefloxacin, Fleroxacin, Lomefloxacin, Norfloxacin, Microbiology, Ofloxacin, Ciprofloxacin