ScholarLens Back to search
1979•PubMedRequires access

The biological activities of norgestrel and its enantiomers.

Robert C. Jones, A. Singer, Richard A. Edgren

Open publisher page 11 citations

Abstract

The dextrorotatory enantiomer of norgestrel has now been tested by oral and parenteral routes in a broad range of biological assays and its inactivity has been confirmed. The active enantiomer has been further compared with the racemate in a similarly broad range of tests, largely by the oral route. Levonorgestrel was twice as potent as the racemate in experiments in which norgestrel was effective. These data reinforce earlier findings that levonorgestrel is responsible for all the biological activity found in norgestrel.

About this research paper

What this paper is about

The dextrorotatory enantiomer of norgestrel has now been tested by oral and parenteral routes in a broad range of biological assays and its inactivity has been confirmed. The active enantiomer has been further compared with the racemate in a similarly broad range of tests, largely by the oral route. Levonorgestrel was twice as potent as the racemate in experiments in which norgestrel was effective. These data reinforce earlier findings that levonorgestrel is responsible for all the biological activity found in norgestrel.

Why it matters

OpenAlex reports 11 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The dextrorotatory enantiomer of norgestrel has now been tested by oral and parenteral routes in a broad range of biological assays and its inactivity has been confirmed. The active enantiomer has been further compared with the racemate in a similarly broad range of tests, largely by the oral route. Levonorgestrel was twice as potent as the racemate in experiments in which norgestrel was effective. These data reinforce earlier findings that levonorgestrel is responsible for all the biological activity found in norgestrel.

Key concepts: Levonorgestrel, Norgestrel, Enantiomer, Biological activity, Chemistry, Pharmacology, Oral route, Population

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The biological activities of norgestrel and its enantiomers. — Research Paper | ScholarLens