ScholarLens Back to search
1985•PubMedRequires access

Alphamethyldopa analgesia: its possible mechanism of action.

G Sivagnanam, C Adithan, Thakur Lc, Ramasamy Raveendran, Bapna Js

Open publisher page 1 citations

Abstract

The analgesic activity of alphamethyldopa (MD) was studied in mice using the acetic acid writhing test and the hot plate method. In the writhing test, MD produced a dose-dependent analgesic effect with an ED 50 of 26.5 mg/kg. The results of the hot plate test confirmed the analgesic activity of MD. Yohimbine, but not naloxone, antagonized the analgesic effect of MD in the writhing test. Atropine antagonized MD analgesia while physostigmine potentiated it. The study suggests that MD analgesia is of the nonopioid type involving both adrenergic and cholinergic systems.

About this research paper

What this paper is about

The analgesic activity of alphamethyldopa (MD) was studied in mice using the acetic acid writhing test and the hot plate method. In the writhing test, MD produced a dose-dependent analgesic effect with an ED 50 of 26.5 mg/kg. The results of the hot plate test confirmed the analgesic activity of MD. Yohimbine, but not naloxone, antagonized the analgesic effect of MD in the writhing test. Atropine antagonized MD analgesia while physostigmine potentiated it. The study suggests that MD analgesia is of the nonopioid type involving both adrenergic and cholinergic systems.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The analgesic activity of alphamethyldopa (MD) was studied in mice using the acetic acid writhing test and the hot plate method. In the writhing test, MD produced a dose-dependent analgesic effect with an ED 50 of 26.5 mg/kg. The results of the hot plate test confirmed the analgesic activity of MD. Yohimbine, but not naloxone, antagonized the analgesic effect of MD in the writhing test. Atropine antagonized MD analgesia while physostigmine potentiated it. The study suggests that MD analgesia is of the nonopioid type involving both adrenergic and cholinergic systems.

Key concepts: Physostigmine, Yohimbine, Analgesic, Hot plate, (+)-Naloxone, Atropine, Hot plate test, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Alphamethyldopa analgesia: its possible mechanism of action. — Research Paper | ScholarLens