The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes)

Topical tretinoin is used by the dermatolovenereologist and aesthetic physicians in patients with mild acne vulgaris, so it is necessary to be investigated. The aim of the study was to assess the effectiveness of benzoyl peroxide gel compared to tretinoin gel on persons with mild acne vulgaris and identify Propionibacterium acnes in patients with mild acne vulgaris. The research method was a clinical trial, double blind randomization. Patients with mild acne vulgaris were randomized in to 2 groups, each group was examined for clinical manifestations (comedone, papules or pustules) examination with sebumeter 815 and Polymerase Chain Reaction, every night each group was treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel in the application, and followed-up in the days of the week 2, 4 and 6. Data were processed with Mann-Whitney test and Chi-Square Test. The results indicated benzoyl peroxide 5% gel and tretinoin 0.05% gel have the same effectiveness in patients with mild acne vulgaris. But, benzoyl peroxide 5% gel decreased blackheads faster compared to papules or pustules with 0.05% tretinoin gel. of sebum. There was no difference in levels of decrease between benzoyl peroxide 5% gel and tretinoin 0.05% gel. Propionibacterium acnes were found in patients with mild acne vulgaris before the treatment of benzoyl peroxide 5% gel and tretinoin 0.05% gel, although not found in all samples.