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Inhibition of postsurgical adhesions by liposomes containing nonsteroidal antiinflammatory drugs.

Kathleen E. Rodgers, Wefki Girgis, Gere S. diZerega, Kate Bracken, Louis Richer

Open publisher page 20 citations

Abstract

Intraperitoneal administration of liposomes containing the nonsteroidal antiinflammatory drugs (NSAID) ibuprofen or tolmetin was tested for their efficacy in the prevention of adhesion formation. Both NSAIDs were able to reduce adhesions in an animal model for moderate adhesion formation. However, tolmetin-containing liposomes were more efficacious than ibuprofen-containing liposomes in the reduction of adhesion formation following bilateral uterine abrasion and devascularization surgery.

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What this paper is about

Intraperitoneal administration of liposomes containing the nonsteroidal antiinflammatory drugs (NSAID) ibuprofen or tolmetin was tested for their efficacy in the prevention of adhesion formation. Both NSAIDs were able to reduce adhesions in an animal model for moderate adhesion formation. However, tolmetin-containing liposomes were more efficacious than ibuprofen-containing liposomes in the reduction of adhesion formation following bilateral uterine abrasion and devascularization surgery.

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OpenAlex reports 20 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Intraperitoneal administration of liposomes containing the nonsteroidal antiinflammatory drugs (NSAID) ibuprofen or tolmetin was tested for their efficacy in the prevention of adhesion formation. Both NSAIDs were able to reduce adhesions in an animal model for moderate adhesion formation. However, tolmetin-containing liposomes were more efficacious than ibuprofen-containing liposomes in the reduction of adhesion formation following bilateral uterine abrasion and devascularization surgery.

Key concepts: Nonsteroidal, Liposome, Ibuprofen, Adhesion, Abrasion (mechanical), Pharmacology, Antiinflammatory drug, Medicine

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Inhibition of postsurgical adhesions by liposomes containing nonsteroidal antiinflammatory drugs. — Research Paper | ScholarLens