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Effect of bovine bone morphogenetic protein and bioactive glass on demineralized bone matrix grafts in the rat muscular pouch.

K J Pajamäki, O H Andersson, T. Sam Lindholm, Kaj H. Karlsson, Antti Yli‐Urpo, R.‐P. Happonen

Abstract

New bone formation induced by allogeneic demineralized bone matrix (DBM) and bone morphogenetic protein (BMP) combined with bioactive glass (BG) was studied in a rat abdominal muscle pouch model. At four weeks the amount of new bone was not influenced by DBM combined with BMP and/or bioactive glass. The mean proportional areas of new bone varied among different DBM test groups from 8.6% to 13.4%. New bone was induced in inactivated DBM samples containing BG, while no bone formation was seen in DBM samples without BG. The results indicate that bioactive glass favours bone induction in inactivated allogeneic bone matrix.

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Key concepts: Demineralized bone matrix, dBm, Bioactive glass, Bone morphogenetic protein, Bone matrix, Pouch, Matrix (chemical analysis), Bone morphogenetic protein 2