2001•PubMedRequires access

[Fatal rhabdomyolysis caused by cerivastatin].

André Jacques Scheen

Abstract

Cerivastatin was recently withdrawn from the market after the report of more than 30 deaths in the United-States among patients receiving a combination of cerivastatin and gemfibrozil, a fibrate which is not anymore on the Belgian market. The cause of death was attributed to severe rhabdomyolysis. Cases were also reported among patients treated by cerivastatin only. Recommendations for better use of lipid-lowering drugs are given in order to optimize the benefit/risk ratio of such treatment.

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Key concepts: Cerivastatin, Gemfibrozil, Fibrate, Rhabdomyolysis, Medicine, Clofibric acid, Internal medicine, Pharmacology