1999•PubMedRequires access

Hepatoprotective activity of ellagic acid against carbon tetrachloride induced hepatotoxicity in rats.

Kavita Singh, Ashwani K. Khanna, Ramesh Chander

Abstract

Administration of CCl4 to normal rats and consequent oral feeding with ellagic acid (50 mg/kg) provided a significant protection against the biochemical alterations in serum and liver produced by CCl4. In vitro experiments showed that liver microsomes from animals treated with ellagic acid and CCl4, decreased lipid peroxidation compared to microsome prepared from rats exposed to CCl4 alone.

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Key concepts: Ellagic acid, Carbon tetrachloride, CCL4, Lipid peroxidation, Microsome, Chemistry, In vitro, Pharmacology