1998•PubMedRequires access
[Diagnostic value of nucleolus organizer regions (NORs) in premalignant and malignant lesions of the cervix].
S Terlikowski, A Lenczewski, S Sułkowski, M Sulkowska, B Musiatowicz, M Kulikowski
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Abstract
The proliferative activity of CIN and SCC lesion was examined using silver-binding argyrophilic nucleolar organizer region (AgNOR) staining. AgNORs have been counted in sections of routinely processed paraffin embedded tissue blocks. The specimens consisted punch biopsies, cones or surgery. The number of black dots (AgNORs) appearing on the nuclei were counted. Significant variation in AgNOR counts were observed between CIN III and SCC compared with the other study groups (p < 0.001). These results suggest that AgNOR counts may be of significance in the evaluation of cervical lesions and could elaborate histopathological diagnosis.