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[Can antibiotic-associated diarrhea be prevented?].

E Loizeau

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Abstract

Post-antibiotic diarrhea is common but rarely serious. The chief cause is changes in the normal intestinal flora. Decrease in the number of bacteria leads to maldigestion of carbohydrates, resulting in osmotic diarrhea. Disappearance of the flora encourages the emergence of resistant strains, e.g. Clostridium difficile. General measures concern the prescription of antibiotics and the use of probiotics. The latter restore and replace the normal flora and prevent more than half of all cases of diarrhea, in particular serious forms and pseudo-membranous colitis. Antibiotics are not accompanied by any complication in 80% of instances. Probiotics should be used in high risk patients: elderly, seriously ill or hospitalised for long periods.

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What this paper is about

Post-antibiotic diarrhea is common but rarely serious. The chief cause is changes in the normal intestinal flora. Decrease in the number of bacteria leads to maldigestion of carbohydrates, resulting in osmotic diarrhea. Disappearance of the flora encourages the emergence of resistant strains, e.g. Clostridium difficile. General measures concern the prescription of antibiotics and the use of probiotics. The latter restore and replace the normal flora and prevent more than half of all cases of diarrhea, in particular serious forms and pseudo-membranous colitis. Antibiotics are not accompanied by any complication in 80% of instances. Probiotics should be used in high risk patients: elderly, seriously ill or hospitalised for long periods.

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Available abstract

Post-antibiotic diarrhea is common but rarely serious. The chief cause is changes in the normal intestinal flora. Decrease in the number of bacteria leads to maldigestion of carbohydrates, resulting in osmotic diarrhea. Disappearance of the flora encourages the emergence of resistant strains, e.g. Clostridium difficile. General measures concern the prescription of antibiotics and the use of probiotics. The latter restore and replace the normal flora and prevent more than half of all cases of diarrhea, in particular serious forms and pseudo-membranous colitis. Antibiotics are not accompanied by any complication in 80% of instances. Probiotics should be used in high risk patients: elderly, seriously ill or hospitalised for long periods.

Key concepts: Diarrhea, Antibiotics, Flora (microbiology), Clostridium difficile, Medicine, Antibiotic-associated diarrhea, Medical prescription, Colitis

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