2004•PubMedRequires access
[Molecular mechanisms of stabilizing proteolytic enzymes. Model of a thermolysin-like microbial metalloproteinase].
Demidiuk, Zabolotskaia Mv, Safrina Dr, Kostrov Sv
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Abstract
The molecular mechanisms that ensure the stability of proteolytic proteins are discussed. The autolytic pathway of protease degradation is emphasized. Experiments aimed at increasing the thermal stability of thermolysin-like metalloproteases are comprehensively described.