1998•PubMedRequires access
[The role of proteolytic enzymes in apoptosis].
M Gacko, Andrzej W. Trochimczuk, H Ostrowska
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Abstract
The literature review dealing with participation of proteolytic enzymes in initiation and execution of apoptosis was done. Cysteine proteases with Asp-X cleavage specificity, called caspases, play the main role in this process. The other proteases such calpains and proteasomes take also part in apoptosis. The proteases degrade proteins of cytoskeleton and structural proteins of nucleus, they also activate proendonucleases.