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1973•The Medical Journal of AustraliaRequires access

A COMPARISON OF CHLOROTHIAZIDE, CHLORTHALIDONE AND CYCLOPENTHIAZIDE IN THE TREATMENT OF HYPERTENSION

William J. Louis, A. E. Doyle, J. K. Dawborn, C. I. Johnston

Open publisher page 14 citations

Abstract

A crossover comparison of chlorthalidone and chlorothiazide was conducted to test the relative effectiveness of these two drugs as adjuncts to antihypertensive drugs in the long-term treatment of hypertension. It was found that 100 mg of chlorthalidone daily produced a high incidence of side effects. Fifty milligrams of chlorthalidone daily and 0-5 gm of chlorothiazide twice daily had similar antihypertensive effects, but even this dose of chlorthalidone was still associated with significant hypo- kalaemia. It is suggested that if chlorthalidone is to be used in the long-term treatment of hypertension, the most appropriate dose for most patients is probably 25 mg daily or 50 mg on alternate days.

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What this paper is about

A crossover comparison of chlorthalidone and chlorothiazide was conducted to test the relative effectiveness of these two drugs as adjuncts to antihypertensive drugs in the long-term treatment of hypertension. It was found that 100 mg of chlorthalidone daily produced a high incidence of side effects. Fifty milligrams of chlorthalidone daily and 0-5 gm of chlorothiazide twice daily had similar antihypertensive effects, but even this dose of chlorthalidone was still associated with significant hypo- kalaemia. It is suggested that if chlorthalidone is to be used in the long-term treatment of hypertension, the most appropriate dose for most patients is probably 25 mg daily or 50 mg on alternate days.

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Available abstract

A crossover comparison of chlorthalidone and chlorothiazide was conducted to test the relative effectiveness of these two drugs as adjuncts to antihypertensive drugs in the long-term treatment of hypertension. It was found that 100 mg of chlorthalidone daily produced a high incidence of side effects. Fifty milligrams of chlorthalidone daily and 0-5 gm of chlorothiazide twice daily had similar antihypertensive effects, but even this dose of chlorthalidone was still associated with significant hypo- kalaemia. It is suggested that if chlorthalidone is to be used in the long-term treatment of hypertension, the most appropriate dose for most patients is probably 25 mg daily or 50 mg on alternate days.

Key concepts: Chlorthalidone, Chlorothiazide, Medicine, Internal medicine, Pharmacology, Diuretic

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A COMPARISON OF CHLOROTHIAZIDE, CHLORTHALIDONE AND CYCLOPENTHIAZIDE IN THE TREATMENT OF HYPERTENSION — Research Paper | ScholarLens