[Evaluation of serum sICAM-1 amd CA-125 in patients with ovarian tumors--preliminary report].

OBJECTIVES: Today's diagnostics and differentiation of ovarian tumour is not efficient enough. Wide spreading tumour immunology of neoplasm presents an opportunity to determine new markers and mechanisms useful for diagnostic and discrimination. The aim of our study was to evaluate concentration of soluble intracellular adhesion molecule-1 (sICAM-1) with CA-125 in ovarian cancer. MATERIAL AND METHOD: Serum of 40 patients undergoing surgical treatment, 32 with ovarian cancer and 8 with benign tumours. Concentration of markers was determined immunoenzymatically. RESULTS: Concentration of sICAM-1 correlated moderately with FIGO stage, tumour volume and CA-125. Mean concentrations between analysed groups were different, but not statistically significant. Determination of sICAM-1 together with CA-125 increased discrimination power of the test. CONCLUSIONS: Determination of sICAM-1 alone seems to have limited application. Addition of this test to CA-125 could improve value of the diagnostic process.