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[Assay of rheumatoid factor by laser nephelometry. A study of 1,000 sera].

J Clot, J Sany, A Clot

Abstract

The detection and assay of Rheumatoid Factor (RF) are possible using laser nephelometry as the reaction between circulating RF and aggregated human IgG results in the formation of soluble immune complexes which scatter the light emitted by the laser. The use of this new method in 1,000 sera shows that this test is more sensitive, positive earlier and more reproducible than the usual reactions of passive agglutination. Its complete automation makes it very rapid and very reliable.

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Available abstract

Key concepts: Nephelometry, Rheumatoid factor, Latex fixation test, Agglutination (biology), Laser, Laser light, Chemistry, Immunology