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Effects of nimodipine on psychological-stress situation in aged rats.

Vincenzo Marino, N Pisanti, Domênico Capone

Abstract

Female aged rats treated with nimodipine, a calcium-blocker dihydropyridine derivative, were submitted to a psychological-stress situation. Nimodipine at the doses of 3 and 6 mg/Kg antagonized the stress-related body-weight decrease and lethality. These findings seem to validate the role of Ca-mediated mechanisms in the physiopathology of stress and the protective effects of the Ca-blockers in the stress-related illnesses.

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Key concepts: Nimodipine, Dihydropyridine, Pathophysiology, Medicine, Body weight, Psychological stress, Calcium, Pharmacology