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[DNA chip and SNP].

Tomomi Kimura, Masaaki Muramatsu

Abstract

Single nucleotide polymorphism (SNP) is high-density genetic marker that could be utilized to dissect genetic traits that influence susceptibility to common diseases and responsiveness to drugs. Requirement for massive SNP analysis has enhanced development of various SNP genotyping technologies. DNA chip is one of such methods, which detects SNPs in parallel on an array of surface bound oligonucleotides. Recent application of DNA chip for high-throughput SNP analysis as well as clinical diagnosis will be presented.

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Available abstract

Key concepts: SNP genotyping, Molecular Inversion Probe, SNP, Single-nucleotide polymorphism, Genotyping, Genetics, SNP array, Biology